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Stability Constants for 1:1 Complexes Formed between2-hydroxypropyl-β-Cyclodextrin with an Average Substitution Degree of 4.4 and Benzene and Alkylbenzenes as Guests by Modified Static Head-Space Gas Chromatography Method |
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| Authors: | Katsumasa Misawa Yoshihiro Saito Kaname Hashizaki Hiroyuki Taguchi Naotake Ogawa Haruhisa Ueda |
| Affiliation: | (1) College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Chiba Funabashi-shi, 274-8555, Japan;(2) Faculty of Pharmaceutical Science, Hoshi University, Ebara 2-4-41, Tokyo Shinagawa-ku, 142-8501, Japan |
| Abstract: | Modified static head-space gas chromatography method (M-SHSGC method) was used to determine the stability constants of benzene and alkylbenzenes with 2-hydroxypropyl-β-cyclodextrin inclusion complexes. The 1:1 stability constants were in agreement with those obtained by conventional SHSGC method. The M-SHSGC method precludes the necessity of the calibration curve by the use of Henry’s law constant of guest. Consequently, it is more advantageous than conventional SHSGC method because the time required to determine the stability constant is markedly reduced. |
| Keywords: | alkylbenzenes benzene inclusion complex modification stability constant static head-space gas chromatography 2-hydroxypropyl-β -cyclodextrin |
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