Hydrogen exchange,alkylation and acylation of potentially tautomeric methyl and methylidene derivatives of pyridine and diazines (Review)

Summary Data on the deuteration, alkylation and acylation reactions of potentially tautomeric methyl and methylidene derivatives of pyridine, pyrimidine and pyrazine in media of varying acidity and basicity have been collated. Whether these reactions occur via the aromatic tautomers, the more reactive methylidene tautomers or predominantly by generation of mesomeric anions from both tautomers is examined.Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 816–829, June, 1995. Original article submitted May 16, 1995.