Direct synthesis of 1,1'-[1,4-phenylenebis(methylene)]-bis- 1,4,8,11-tetraazacyclotetradecane octahydrochloride (AMD 3100) without the use of protecting groups |
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| Authors: | Achmatowicz Michal Hegedus Louis S |
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| Affiliation: | Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA. hegedus@lamar.colostate.edu |
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| Abstract: | A four-step synthesis of the title compound starting from methyl acrylate, ethylenediamine, and dimethyl malonate is reported. The synthesis can be run on a multigram scale and is operationally simple. The use of protecting groups is avoided by utilizing the trioxocyclam as the key coupling intermediate. |
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