Improved method for the diimide reduction of multiple bonds on solid-supported substrates |
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Authors: | Buszek Keith R Brown Neil |
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Affiliation: | Department of Chemistry, Kansas State University, 111 Willard Hall, Manhattan, Kansas 66506, USA. buszekk@umkc.edu |
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Abstract: | A mild and improved method for reducing multiple bonds on various resins with diimide is described. The simple procedure readily generates diimide from 2-nitrobenzenesulfonohydrazide and triethylamine at room temperature. A number of representative multiple bonds in various steric and electronic environments were examined, including polar double bonds such as carbonyl and azo, for ease and selectivity of reduction. A general trend of reactivity was identified which revealed, inter alia, that terminal olefins, 1,2-disubstituted olefins, electron-poor olefins, and terminal alkynes were the most easily reduced. |
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