One-step synthesis of the tricyclic core of martinellic acid from 2-(cyanomethyl)-3-oxo-N-arylbutanamides |
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| Authors: | Zhang Zhiguo Zhang Qian Yan Zihong Liu Qun |
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| Affiliation: | Department of Chemistry, Northeast Normal University, Changchun 130024, China. |
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| Abstract: | A SnCl4.5H2O-mediated facile and efficient one-step synthesis of the tricyclic core of martinellic acid from readily available 2-(cyanomethyl)-3-oxo-N-arylbutanamides was developed and a mechanism involving consecutive hydrolysis of a cyano group and a double annulation process is proposed. |
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