| Studies on Tripolycyanamide Formaldehyde Resin-Pd Complex and Its Use in the Synthesis of the Branch of Paclitaxel |
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| 引用本文： | 齐传民 杨凌春 王力元. Studies on Tripolycyanamide Formaldehyde Resin-Pd Complex and Its Use in the Synthesis of the Branch of Paclitaxel[J]. 中国化学, 2003, 21(12): 1536-1539. DOI: 10.1002/cjoc.20030211204 |
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| 作者姓名： | 齐传民 杨凌春 王力元 |
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| 作者单位： | DepartmentofChemistry,BeijingNormalUniversity,Beijing100875,China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 1710 0 8) |
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| 摘 要： | A novel method was developed to prepare the branch of paclitaxel using 2,4-dichlorophenylaldehyde as the starting material.The branch was synthesized through condensation, cydoaddltion and catalyzing hydrogenation of dichlorophenyl intermediate. Tripolycyanamide formaldehyde resin-Pd complex as hydrogenation catalyst has been studied. The influence of temperature and N/Pd atomic ratio of the catalyst on the effect of catalytic hydrogenation was investigated and the optimum conditious were found. Because of the mild cyclization reaction condition, convenient asymmetric resolution operation and high yield, the synthetic route was practical.
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| 关 键 词： | 三聚氰胺甲醛 树脂钯配合物 合成 红豆杉醇 抗癌药物 金属催化剂 |
Studies on Tripolycyanamide Formaldehyde Resin-Pd Complex and Its Use in the Synthesis of the Branch of Paclitaxel |
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| QI,Chuan-Min YANG,Ling-Chun WANG,Li-Yuan. Studies on Tripolycyanamide Formaldehyde Resin-Pd Complex and Its Use in the Synthesis of the Branch of Paclitaxel[J]. Chinese Journal of Chemistry, 2003, 21(12): 1536-1539. DOI: 10.1002/cjoc.20030211204 |
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| Authors: | QI Chuan-Min YANG Ling-Chun WANG Li-Yuan |
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| Affiliation: | QI,Chuan-Min YANG,Ling-Chun WANG,Li-YuanDepartment of Chemistry,Beijing Normal University,Beijing 100875,China |
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| Abstract: | A novel method was developed to prepare the branch of paclitaxel using 2,4-dichlorophenylaldehyde as the starting material. The branch was synthesized through condensation,cycloaddition and catalyzing hydrogenation of dichlorophenyl intermediate. Tripolycyanamide formaldehyde resin-Pd complex as hydrogenation catalyst has been studied. The influence of temperature and N/Pd atomic ratio of the catalyst on the effect of catalytic hydrogenation was investigated and the optimum conditions were found. Because of the mild cyclization reaction condition,convenient asymmetric resolution operation and high yield,the synthetic route was practical. |
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| Keywords: | paclitaxel catalytic hydrogenation polymer-Pd catalyst |
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