|
|||||
|
|
Determination of N-Nitroso Compounds in the Environment of a Metal Factory Using Metalworking Fluids |
|
| Authors: | Sami Fadlallah Sam F Cooper Michel Fournier Daniel Drolet Guy Perrault |
| Institution: | 1. Institut National de la Recherche Scientifique, INRS-Santé, Université du Québec , 245, boulevard Hymus, Pointe-Claire, Québec, H9R 1G6, Canada;2. Département des Sciences Biologiques , Université du Québec à Montréal , Montréal, (Québec), C.P. 8888, Succursale “A”, H3C 3P8, Canada;3. Institut National de la Recherche Scientifique, INRS-Santé, Université du Québec , 245, boulevard Hymus, Pointe-Claire, Québec, H9R 1G6, Canada;4. Département des Sciences Biologiques , Université du Québec à Montréal , Montréal, (Québec), C.P. 8888, Succursale “A”, H3C 3P8, Canada;5. Institut de recherche en santé et en sécurité du travail du Québec (IRSST) , 505 ouest, de Maisonneuve, Montréal, Québec, H3A 3C2, Canada |
| Abstract: | Abstract By use of GLC-ECD and HPLC-TEA techniques for N-nitroso compounds, N-nitroso-diethanolamine (NDELA) has been found in concentrations of 1.4–6.0 μg/m3 and 1.3–5.0μg/m3 respectively in all four air samples collected in the environment of a metalworking plant during metallurgical operations. NDELA was quantitated in air samples by GLC-ECD after converting it to its trifluoroacetyl derivative by reaction with the appropriate anhydride. NDELA was analyzed without derivatization in air samples using HPLC-TEA method. N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) were also identified and later determined in two out of four air samples in concentrations of 0.08μg/m3 (for NDMA in both samples) and 0.14–0.16μg/m3 (for NDEA) using GLC-TEA procedure. The described method did not cause artifactual formation of N-nitrosomethyl-N-butylamine (NMBA) when methyl-N-butylamine was used as an internal marker of nitrosation during collection of NDELA in impinger traps. |
| Keywords: | N-nitroso compounds GLC-ECD HPLC-TEA GLC-TEA |