Synthesis and antimicrobial activity of 4-aza-5α-sitostane and the 4-methyl derivative

Synthesis of 4-aza-5α-sitostane (IX), and 4-methyl-4-aza-5α-sitostane (XII) were accomplished through a set of reactions involving oxidative opening of ring A of α,β-unsaturated ketone, ring closure, followed by catalytic hydrogenation and lithium aluminum hydride reduction, respectively. The antimicrobial activity for X and XII is reported.