Benzyl radical addition reaction through the homolytic cleavage of a benzylic C-H bond |
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| Authors: | Ueda Masafumi Kondoh Eiko Ito Yuta Shono Hiroko Kakiuchi Maiko Ichii Yuki Kimura Takahiro Miyoshi Tetsuya Naito Takeaki Miyata Okiko |
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| Institution: | Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan. |
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| Abstract: | Direct generation of a benzyl radical by C-H bond activation of toluenes and the addition reaction of the resulting radical to an electron deficient olefin were developed. The reaction of dimethyl fumarate with toluene in the presence of Et(3)B as a radical initiator at reflux afforded 2-benzylsuccinic acid dimethyl ester in good yield. |
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