| 用于基因传递系统控制释放的可生物降解高分子材料 |
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| 引用本文： | 付慧莉,程巳雪,卓仁禧.用于基因传递系统控制释放的可生物降解高分子材料[J].高分子学报,2009,0(2):97-103. |
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| 作者姓名： | 付慧莉 程巳雪 卓仁禧 |
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| 作者单位： | 武汉大学化学与分子科学学院,生物医用高分子材料教育部重点实验室,武汉,430072 |
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| 摘 要： | 综述了用于基因传递系统控制释放的各类高分子材料包括天然高分子及其衍生物、合成高分子,并介绍了它们在基因治疗和组织工程领域中的应用.
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| 关 键 词： | 可生物降解高分子 基因传递 组织工程 |
| 收稿时间： | 2008-09-02 |
BIODEGRADABLE POLYMERS FOR CONTROLLED RELEASE OF GENE DELIVERY SYSTEMS |
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| FU Huili,CHENG Sixue,ZHUO Renxi.BIODEGRADABLE POLYMERS FOR CONTROLLED RELEASE OF GENE DELIVERY SYSTEMS[J].Acta Polymerica Sinica,2009,0(2):97-103. |
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| Authors: | FU Huili CHENG Sixue ZHUO Renxi |
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| Institution: | Key Laboratory of Biomedical Polymers of Ministry of Education;College of Chemistry and Molecular Sciences;Wuhan University;Wuhan 430072 |
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| Abstract: | Gene therapy shows great promise to treat both acquired and inherited diseases.Numerous gene delivery systems based on viral and nonviral vectors have been developed to protect plasmid DNA and facilitate cell binding and internalization.Nevertheless,it is still a challenge to deliver DNA to target cell population and particular location by injection or systematic delivery due to the immune responses and DNA complex aggregation,degradation,and clearance from the tissue.Polymers loaded with gene or vector/gen... |
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| Keywords: | Biodegradable polymers Gene delivery Tissue engineering |
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