| Resonance Rayleigh Scattering Method for the Determination of Raloxifene with Evans Blue |
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| 作者姓名： | 范莉 刘绍璞 杨大成 胡小莉 |
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| 作者单位： | FAN，Li LIU，Shao-Pu YANG，Da-Cheng HU，Xiao-LiInstitute of Environmental Chemistry，Southwest China Normal University，Chongqing 400715，China |
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| 基金项目： | theNationalNaturalScienceFoundationofChina (No.2 9875 0 19) |
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| 摘 要： | ＩｎｔｒｏｄｕｃｔｉｏｎＩｎｒｅｃｅｎｔｙｅａｒｓ ,ｒｅｓｏｎａｎｃｅＲａｙｌｅｉｇｈｓｃａｔｔｅｒｉｎｇ(ＲＲＳ)ｍｅｔｈｏｄａｓａｎｅｗａｎａｌｙｔｉｃａｌｔｅｃｈｎｉｑｕｅｈａｓｂｅｅｎｅｘｔｅｎｓｉｖｅｌｙｓｔｕｄｉｅｄａｎｄｗｉｄｅｌｙｕｓｅｄｔｏｔｈｅｄｅｔｅｒｍｉｎａｔｉｏｎｏｆｓｏｍｅｂｉｏｌｏｇｉｃａｌｍａｃｒｏｍｏｌｅｃｕｌｅｓ ,ｓｕｃｈａｓｎｕｃｌｅｉｃａｃｉｄ ,1 4 ｐｒｏｔｅｉｎ5 8ａｎｄｈｅｐａｒｉｎ ,9ａｓｗｅｌｌａｓｉｎｏｒｇａｎｉｃｉｏｎ ,10 14 ｄｕｅｔｏｉｔｓｓｉ…
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Resonance Rayleigh Scattering Method for the Determination of Raloxifene with Evans Blue |
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| FAN,Li LIU,Shao-Pu YANG,Da-Cheng HU,Xiao-LiInstitute of Environmental Chemistry,Southwest China Normal University,Chongqing ,China.Resonance Rayleigh Scattering Method for the Determination of Raloxifene with Evans Blue[J].Chinese Journal of Chemistry,2002,20(12):1552-1556. |
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| Authors: | FAN Li LIU Shao-Pu YANG Da-Cheng HU Xiao-LiInstitute of Environmental Chemistry Southwest China Normal University Chongqing China |
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| Institution: | FAN,Li LIU,Shao-Pu YANG,Da-Cheng HU,Xiao-LiInstitute of Environmental Chemistry,Southwest China Normal University,Chongqing 400715,China |
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| Abstract: | The intensity of resonance Rayleigh scattering (RRS) of Evans blue (EB) or raloxifene hydrochloride (Ralo) is very weak, but it can be enhanced significantly and a new RRS spectrum appears when both of them interact to form an ion‐association complex in sodium acetate‐hydrochloric acid buffer solution at pH 1.8. The intensity of RRS is directly proportional to the concentration of Ralo in the range of 0–8.3 μg · mL?1, and the detection limit for Ralo (σ = 3) is 18.9 ng·mL?1. The method has high sensitivity and fairly good selectivity. Based on the above evidences, a new facile method for the determination of trace amount of Ralo has been established with satisfactory results. |
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| Keywords: | resonance Rayleigh scattering raloxifene Evans blue ion-association complex |
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