Solid State Radical Recombination and Charge Transfer across the Boundary between Indomethacin and Silica under Mechanical Stress期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Solid State Radical Recombination and Charge Transfer across the Boundary between Indomethacin and Silica under Mechanical Stress

Authors:	Tomoyuki Watanabe Susumu HasegawaNaoki Wakiyama Fusao UsuiAkira Kusai Tetsuhiko IsobeMamoru Senna

Institution:	^a Product Development Laboratories, Sankyo Co. Ltd. 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan ^b Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama, 223-8522, Japan

Abstract:	A composite of indomethacin (IM) and SiO₂ was prepared in a solid state by cogrinding. Dehydration was observed as a consequence of a chemical reaction between silanol groups of SiO₂ and carboxyl groups of IM. Several specific radical species found on separately ground SiO₂ disappeared preferentially after cogrinding as a result of their recombination. These chemical interactions under mechanical stress bring about a charge transfer, as confirmed by X-ray photoelectron spectroscopy, leading to Si-O-C bridging bond formation at the IM/SiO₂ interface.

Keywords:	silica composite mechanochemical mechanoradical charge transfer electronegativity equalization
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