A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks

Despite the fact that numerous infection-resistant surfaces have been developed to prevent bacterial colonization and biofilm formation,developing a stable,highly antibacterial and easily produced surface remains a technical challenge.As a crucial structural component of biofilm,extracellular DNA (eDNA) can facilitate initial bacterial adhesion,subsequent development,and final maturation.Inspired by the mechanistic pathways of natural enzymes (deoxyribonuclease),here we report a novel antibacterial surface by employing cerium (Ce(Ⅳ)) ion to mimic the DNA-cleavage ability of natural enzymes.In this process,the coordination chemistry of plant polyphenols and metal ions was exploited to create an in situ metal-phenolic film on substrate surfaces.Tannic acid (TA) works as an essential scaffold and Ce(Ⅳ) ion acts as both a cross-linker and a destructor of eDNA.The Ce(Ⅳ)-TA modified surface exhibited highly enhanced bacteria repellency and biofilm inhibition when compared with those of pristine or Fe(Ⅲ)-TA modified samples.Moreover,the easily produced coatings showed high stability under physiological conditions and had nontoxicity to cells for prolonged periods of time.This as-prepared DNA-cleavage surface presents versatile and promising performances to combat biomaterial-associated infections.