PRELIMINARY STUDIES ON THE SYNTHESIS AND CHARACTERIZATION OF OXY-AND THIO-DIACETIC ACID HYDRAZITION AND THEIR FIRST-ROW TRANSITION METAL COMPLEXES

It has been made certain that thio-and oxy-diacetic acid hydrazidesare potential anticancer compounds.However,their ability to formcomplexes with transition metals and the properties of the complexes thusformed have not been studied.Employing a new potential anticancer ligand1,2-bis(thioacetic acid hydrazide)ethane prepared in our lab,along withligands oxydiacetic hydrazide and 1,2-bis(oxyacetic acid hydrazide)ethane,a series of 11 new first-row transition metal(M=Zn~(2+),Cu~(2+),Co~(2+),Ni~(2+))complexes with each of the above three ligands have been synthesizedand characterized by means of elemental analyses,IR,TG and X-raypowder diffraction.

PRELIMINARY STUDIES ON THE SYNTHESIS AND CHARACTERIZATION OF OXY-AND THIO-DIACETIC ACID HYDRAZITION AND THEIR FIRST-ROW TRANSITION METAL COMPLEXES

It has been made certain that thio-and oxy-diacetic acid hydrazides are potential anticancer compounds^[1.2].However, their ability to form complexes with transition metals and the properties of the complexes thus formed have not been studied.Employing a new potential anticancer ligand 1, 2-bis（thioacetic acid hydrazide）ethane prepared in our lab, along with ligands oxydiacetic hydrazide and 1, 2-bis（oxyacetic acid hydrazide）ethane, a series of 11 new first-row transition metal(M=Zn²⁺, Cu²⁺, Co²⁺, Ni²⁺)complexes with each of the above three ligands have been synthesized and characterized by means of elemental analyses, IR, TG and X-ray powder diffraction.