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Dihydronaphthalenones from endophytic fungus Fusarium sp. BCC14842 |
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| Authors: | Jittra KornsakulkarnKulvadee Dolsophon Nattawut BoonyuenTanapong Boonruangprapa Pranee RachtaweeSamran Prabpai Palangpon Kongsaeree Chawanee Thongpanchang |
| Institution: | a National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand b Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand c Center for Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand |
| Abstract: | Eleven new dihydronaphthalenones 1-11, together with five known compounds; 5-hydroxydihydrofusarubin C (12), javanicin, bostrycoidin, anhydrofusarubin, and 3-O-methylfusarubin, were isolated from the endophytic fungus Fusarium sp. BCC14842. Structures were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. Javanicin, 3-O-methylfusarubin, compounds 3 and 7 exhibited antimycobacterial and cytotoxic activities. Javanicin also displayed antifungal activity with IC50 of 6.16 μg/mL, while compounds 2, 4, 5, 8, and 12 showed only cytotoxic activity. |
| Keywords: | Dihydronaphthalenones Bioactive secondary metabolites Endophytic fungi Fusarium sp |
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