Physicochemical aspects of drug delivery and release from polymer-based colloids |
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| Affiliation: | 1. Research Centre for Nanometer-Scale Science and Advanced Materials, NANOSAM, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland;2. Bionanopark Ltd., Łódź, Poland;1. State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China;2. School of Engineering, University of Warwick, Coventry CV4 7AL, UK;1. Cellular Neurobiology and Molecular Chemistry of the Central Nervous System Group, Faculty of Pharmacy, University of Castilla-La Mancha, Albacete, Spain;2. Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain |
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| Abstract: | Recent advances in the preparation/loading, surface properties, and applications of polymer-based colloidal drug delivery and release systems, such as block copolymer micelles, polymer nano- and microparticles, polymer-modified liposomes, and chemical and physical hydrogels are presented. Drug release from polymer-based systems is affected by the drug–polymer interactions as well as the polymer microstructure and dissociation/erosion properties. Surface modification with poly(ethylene oxide) has become common in improving the biocompatibility and biodistribution of drug delivery carriers. Site-specific drug delivery can be achieved by polymer-based colloidal drug carriers when ligands of targeting information are attached on the carrier surface or when a phase transition is induced by an external stimulus. While significant progress in being made, many challenges remain in preserving the biological activity and attaining the desired drug release properties, especially for protein and DNA drugs. |
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