| 铅染毒对大鼠体内钙、锌、铁元素的影响研究 |
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| 引用本文： | 冯福建,王兰,虞江萍,李兰芳,戴宝强,曹秀芬. 铅染毒对大鼠体内钙、锌、铁元素的影响研究[J]. 广东微量元素科学, 2001, 8(4): 23-26 |
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| 作者姓名： | 冯福建 王兰 虞江萍 李兰芳 戴宝强 曹秀芬 |
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| 作者单位： | 1. 中国科学院地理科学与资源研究所
2. 中国中医科学研究院 |
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| 摘 要： | Wistar大鼠每天腹腔注射醋酸铅649mg/kg，在第4周醋酸铅剂量降至329．5mg/kg，8周停止染毒。结果表明，随着铅染毒，大鼠出现高尿铅、高尿锌、高尿钙；脑、肝、肾中铁、锌、钙却都有不同程度提高，肝脏中锌、钙、铁、肾脏中锌、钙增加极明显；在8周停止染毒后，脑铅含量大幅度降低（P＜0．01），肝脏铅却梢有上升（P＞0．05），肾铅急剧增加，从47．9320μmol／L升至633．85μmol／L，大约上升13倍（P＜0．01）。
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| 关 键 词： | 大鼠 铅染毒 金属元素 钙 锌 铁 含量变化 协同作用 拮抗作用 |
| 文章编号： | 1006-446X(2001)04-0023-04 |
| 修稿时间： | 2001-02-07 |
Effect Research of Lead Poisoning on Some Metals Levels in Rats Body |
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| FENG Fu-jian,WANG Lan,YU Jiang-ping,LI Lan-fang,DAI Bao-qiang,CAO Xiu-fang. Effect Research of Lead Poisoning on Some Metals Levels in Rats Body[J]. Trace Elements Science, 2001, 8(4): 23-26 |
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| Authors: | FENG Fu-jian WANG Lan YU Jiang-ping LI Lan-fang DAI Bao-qiang CAO Xiu-fang |
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| Abstract: | Wistar rats were injected intraperitoneally with lead acetate in dosage of 659 mg/kg body every day.At the 4th week,the dosage of lead acetate was reduced to 329.5 mg/kg body.After the 8th week poisoning was stopped.The results show that the rats appear higher urinary Pb,Zn,Ca along with lead poisoning.Calcium,zinc and iron concentrations in brain,liver and kidney all rise to a certain extent.Liver calcium,zinc and iron,kidney calcium and zinc increase obviously(P＜0.01).After the 8th week,brain lead decrease obviously(P＜0.01).liver lead does not change obviously.Kidney lead raises extremely and rises about 13 times from 47.93 μmol/L to 633.85 μmol/L(P＜0.01). |
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| Keywords: | Wistar rat lead poisoning some metals levels |
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