Spectroscopic and structural study of the ambazone hydrochloride |
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Authors: | Marieta Muresan-Pop Irina Kacsó Carmen Tripon Z Moldovan Gh Borodi S Simon I Bratu |
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Institution: | (1) Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Romania;(2) National Institute for R&D of Isotopic and Molecular Technologies, P.O. Box 700, 400293 Cluj-Napoca, Romania; |
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Abstract: | Ambazone, a well-known antimicrobial compound, presents also oncostatic properties. The solid form, obtained by using solvent-drop
grinding procedure, was characterized by using several physical techniques such as FTIR, X-ray photoelectron spectroscopy,
13C NMR and 15N NMR spectroscopies, thermal analysis, X-ray powder diffraction and mass spectrometry. Based on these data, it was demonstrated
that an ambazone–hydrochloride was obtained: new vibrations corresponding to NH2
+ were identified. DTA–TG–DSC and MS data revealed that a new crystal type has been obtained. X-ray diffraction data allowed
the determination of the lattice parameters and the most probable space group P
21/c
was established also with only one molecule per asymmetric unit. |
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Keywords: | |
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