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Transport engineering in microbial cell factories producing plant-specialized metabolites
Authors:Zeinu Mussa Belew  Michal Poborsky  Hussam Hassan Nour-Eldin  Barbara Ann Halkier
Institution:DynaMo Center of Excellence, Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark
Abstract:Transport engineering strategies use altered expression of transporter proteins to change metabolite distribution within an organism. The production of plant specialized metabolites in microbial cell factories encounters a set of challenges that could benefit from the implementation of transport engineering technology. The range of challenges includes premature pathway termination due to secretion of intermediates, feedback inhibition due to inefficient export of final products, low yields in bioconversion processes due to inefficient import of precursors, and poor connectivity between subcellular compartments expressing different parts of complex biosynthetic pathways. We highlight the latest examples of transport engineering in microbial cell factories producing plant specialized metabolites, identify the current knowledge gap, and propose future research for advancing the field.
Keywords:Transport engineering  Plant specialized metabolites  Microbial cell factories  Pathway engineering  Metabolic engineering  Feedback inhibition
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