A Highly Sensitive Fluorescent Probe for HClO and Its Application in Live Cell Imaging |
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| Authors: | Qing-Ping Zuo Zuo-Jun Li Yong-Hua Hu Bin Li Li-Hua Huang Chun-Jiang Wang Shi-Kun Liu Hai-Qiang Liao |
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| Institution: | Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China. |
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| Abstract: | A new rhodamine-based probe 1 was designed and synthesized as a new fluorescent molecular probe for HClO in PBS buffer at physiological condition. The free probe 1 almost nonfluorescence, however, a drastic enhancement of fluorescence intensity was observed in the presence of HClO. The new probe 1 exhibits good sensitivity and selectivity for HClO over other reactive oxygen and/or nitrogen species in PBS buffer, and the probe was successfully applied to image endogeneous HClO in the living cells. |
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