Antimicrobial activity of new bicyclic lactones with three or four methyl groups obtained both synthetically and biosynthetically |
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Authors: | Katarzyna Wińska Małgorzata Grabarczyk Wanda Mączka Barbara Żarowska Gabriela Maciejewska Mirosław Anioł |
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Affiliation: | 1. Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroc?aw, Poland;2. Department of Biotechnology and Food Microbiology, Wroclaw University of Environmental and Life Sciences, Che?mońskiego 37/41, 51-630 Wroc?aw, Poland;3. Faculty of Chemistry, Wroc?aw University of Technology, Wybrze?e Wyspiańskiego 27, 50-370 Wroc?aw, Poland |
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Abstract: | Ten new derivatives of isophorone were obtained through a five-step synthesis. Among the products were several unsaturated, bicyclic lactones with three or four methyl groups. These lactones were used as the substrates for biotransformation mediated by selected fungal strains (Fusarium species, Syncephalastrum racemosum, Cunninghamella japonica, Penicillium species, Absidia species, and Pleurotus ostreatus). Four new hydroxylactones were obtained as a result of biotransformation. Because the unsaturated lactone with four methyl groups was a diastereoisomeric mixture, a structural analysis was conducted. The hydroxylactones were also included in this analysis. Both the unsaturated lactones and hydroxylactones were examined for their antimicrobial activity. It was found that some of these compounds exhibited growth inhibition against pathogenic strains of bacteria (Staphylococcus aureus, Pseudomonas fluorescens), yeasts (Candida albicans) and filamentous fungi (Alternaria sp., Penicillium sp.). All obtained compounds were also subjected to scent analysis. |
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Keywords: | Unsaturated lactones Biotransformation Hydroxylation Antimicrobial activity Odour |
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