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One-pot three-component reaction for the synthesis of pyran annulated heterocyclic compounds using DMAP as a catalyst
Authors:Abu T Khan  Mohan LalShahzad Ali  Md Musawwer Khan
Institution:Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781 039, India
Abstract:The one-pot three-component reaction for the synthesis of pyran annulated heterocycles is reported by condensing aromatic aldehydes, ethyl cyanoacetate, or malononitrile and C-H activated acidic compounds in the presence of catalytic amount of 4-(dimethylamino)pyridine (DMAP) in ethanol under reflux conditions. The significant features of the present protocol are simple, environmentally benign, high yields, non-aqueous work-up procedure, no chromatographic separation and recyclability of the catalyst.
Keywords:Multicomponent reactions  Pyran annulated heterocyclic derivatives  4-Hydroxy-coumarin  4-(Dimethylamino)pyridine (DMAP)
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