Viscoelastic characterization of compacted pharmaceutical excipient materials by analysis of frequency-dependent mechanical relaxation processes |
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Authors: | K Welch S Mousavi B Lundberg M Strømme |
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Institution: | 1.Department of Engineering Sciences, The ?ngstr?m Laboratory,Uppsala University,Uppsala,Sweden |
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Abstract: | A newly developed method for determining the frequency-dependent complex Young's modulus was employed to analyze the mechanical
response of compacted microcrystalline cellulose, sorbitol, ethyl cellulose and starch for frequencies up to 20 kHz. A Debye-like
relaxation was observed in all the studied pharmaceutical excipient materials and a comparison with corresponding dielectric
spectroscopy data was made. The location in frequency of the relaxation peak was shown to correlate to the measured tensile
strength of the tablets, and the relaxation was interpreted as the vibrational response of the interparticle hydrogen and
van der Waals bindings in the tablets. Further, the measured relaxation strength, holding information about the energy loss
involved in the relaxation processes, showed that the weakest material in terms of tensile strength, starch, is the material
among the four tested ones that is able to absorb the most energy within its structure when exposed to external perturbations
inducing vibrations in the studied frequency range. The results indicate that mechanical relaxation analysis performed over
relatively broad frequency ranges should be useful for predicting material properties of importance for the functionality
of a material in applications such as, e.g., drug delivery, drug storage and handling, and also for clarifying the origin of hitherto unexplained molecular processes. |
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Keywords: | 81 05 Rm Porous materials granular materials 62 20 -x Mechanical properties of solids 81 70 Bt Mechanical testing impact tests static and dynamic loads 61 41 +e Polymers elastomers and plastics |
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