New strategy towards the efficient solid phase synthesis of cyclopeptides |
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| Authors: | Thomas Berthelot Georges Laïn Gérard Déléris |
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| Institution: | a CNRS UMR 5084 CNAB, Groupe de Chimie Bio Organique, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
b INSERM E0113, Laboratoire des Mécanismes Moléculaires de l'Angiogenèse, Université Bordeaux 1, 33405 Talence, France |
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| Abstract: | Synthetic cyclopeptides, and particularly those designed from VEGF structure, present considerable interest for the development of nanodevices devoted to tumor imaging or drug delivery. In order to obtain functionalizable cyclopeptides, we herein present a novel efficient way based on Fmoc-Lys-ODmab use, which was applied to the synthesis of c(PHGRIK) cyclopeptide. |
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| Keywords: | Nanodevice Cyclopeptides On-resin cyclization Dmab ester Lysine |
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