A synthesis of novel N-sulfonylated β-amino acids |
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| Authors: | Dirk Freitag |
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| Institution: | Technische Universität Dresden, Institut für Organische Chemie, Bergstraße 66, D-01069 Dresden, Germany |
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| Abstract: | Novel N-sulfonyl β-amino acids were efficiently prepared in a seven-step synthesis starting from Boc protected methanesulfonamide and terminal epoxides. A zinc-mediated allylation of cyclic N-sulfonyl imines readily derived from these building blocks served as a key operation of this sequence. |
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| Keywords: | β-Amino acids γ-Sultams Sulfonyl imines Sulfonamides Allylation Oxidative cleavage |
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