Palladium catalyzed synthesis of Ca indicators with aryl bithiophene and terthiophene fluorophores |
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Authors: | Noë l Boens,Subhendu S. Samanta |
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Affiliation: | Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium |
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Abstract: | Five new fluorescent indicators for Ca2+ were synthesized using the Stille reaction. They all consist of the tricarboxylate chelator APTRA (o-aminophenol-N,N,O-triacetic acid) linked to a (substituted) bithiophene or terthiophene fluorophore. The dissociation constants Kd measured via fluorimetric titrations at 21 °C in 100 mM KCl buffered solution, pH 7.05, for the Ca2+ complexes with the new probes are in the range between 10 and 40 μM. |
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Keywords: | Fluorescent indicator Thiophene Stille reaction Ca2+ |
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