|
|||||
|
|
New cyclic depsipeptides from the green alga Bryopsis species; application of a carboxypeptidase hydrolysis reaction to the structure determination |
|
| Authors: | Andrey Dmitrenok Takashi Iwashita Bryan Sakamoto Michio Namikoshi |
| Affiliation: | a Suntory Institute for Bioorganic Research, 1-1-1, Wakayamadai, Shimamoto, Mishima, Osaka 618-8503, Japan b Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii, HI 96822, USA c Department of Ocean Science, Tokyo University of Marine Science and Technology, 4-5-7, Konan, Minato-ku, Tokyo 108-8477, Japan |
| Abstract: | New cyclic depsipeptides, kahalalides P (1) and Q (2), were isolated from the Hawaiian green alga Bryopsis sp. The sequential positions of the dl anti-podal amino acids were determined by a carboxypeptidase hydrolysis reaction. This enzymatic method will be applicable to the structure determination of other non-ribosomal peptides. The absolute chemistry of 3-hydroxy-9-methyldecanoic acid in kahalalides P and Q were determined by the recently introduced convenient Mosher ester procedure. |
| Keywords: | Marine natural product Green alga Depsipeptide Carboxypeptidase |
| 本文献已被 ScienceDirect 等数据库收录！ | |