Malonganenones A-C, novel tetraprenylated alkaloids from the Mozambique gorgonian Leptogorgia gilchristi |
| |
Authors: | Robert A. Keyzers Michael H. Schleyer Denver T. Hendricks |
| |
Affiliation: | a Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa b Oceanographic Research Institute, Durban 4056, South Africa c Division of Medical Biochemistry, Observatory, Medical School, University of Cape Town, Cape Town 7925, South Africa |
| |
Abstract: | Three novel tetraprenylated alkaloids, malonganenones A-C (1-3), were isolated from the gorgonian Leptogorgia gilchristi collected near Ponto Malongane, Mozambique. Compound 1 is the first 3,7-disubstituted hypoxanthine to be discovered from a marine source, while 2 and 3 represent the first formamides to be isolated from gorgonians. The unexpected facile exchange of the formamide proton of 2 with a deuteron originating from the NMR solvent used for spectroscopic analysis hampered initial attempts at the structural elucidation of this compound. The anti-oesophageal cancer activities of 1-3 are compared with that of rietone (4), a related triprenylated compound previously isolated from a South African soft coral. |
| |
Keywords: | Leptogorgia Gorgonian Tetraprenyl Formamide Hypoxanthine Deuterium exchange |
本文献已被 ScienceDirect 等数据库收录! |
|