Asymmetric synthesis of phosphonic acid analogues for acylcarnitine |
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Authors: | Takehiro Yamagishi Tsutomu Yokomatsu |
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Affiliation: | School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan |
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Abstract: | Phosphonic acid analogues of acylcarnitine were prepared in an optically active form expecting CPT I inhibitory activities. The synthetic methodology was based on catalytic asymmetric dihydroxylation of β,γ-unsaturated phosphonates and subsequent regioselective amination via the cyclic sulfates. |
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Keywords: | Acylcarnitine Phosphonic acid Asymmetric dihydroxylations Regioselectivity |
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