Synthesis of 1,2,4-triazole dendrimers

A convergent synthetic strategy towards novel 1,2,4-triazole dendrimers, in which 3,5-dichloro-4-(4-methoxyphenyl)-4H-1,2,4-triazole was used as the heterocyclic building block, was successfully explored. Nucleophilic aromatic substitution at this novel AB₂-monomer was used as the key step in the propagation of the heterocyclic dendrons and these dendrons were attached to both a 1,3,5-triazine and a methylene core. The peripheral 1,2,4-triazole could be varied not only by nucleophilic aromatic substitution but also by Suzuki cross-coupling. The presented dendrimers are promising candidates to be used in applications where the large number of heteroatoms can be exploited or a better resistance to the applied conditions is required.