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Baylis-Hillman adducts between pyridine carboxaldehyde derivatives and cyclic enones |
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| Authors: | P Narender M Ravinder GYSK Swamy V Jayathirtha Rao |
| Institution: | a Organic Chemistry Division-II, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India b Laboratory of Crystallography, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India |
| Abstract: | Baylis-Hillman (BH) adducts were synthesized using pyridinecarboxaldehyde derivatives and cyclic enones. The Baylis-Hillman reaction was examined by employing various organic tertiary bases and solvents. It was observed that DBU in MeOH as well as imidazole and N-methylimidazole in aqueous MeOH are very effective. These pyridinecarboxaldehydes were reactive and efficient towards the Baylis-Hillman reaction and the resulting adducts are highly stable. The crystal structure for one of the BH adducts was determined. |
| Keywords: | Baylis-Hillman reaction Substituted 2-chloropyridine-3-carboxaldehydes Cyclic enones Organic tertiary bases Solvents Baylis-Hillman adducts X-ray crystal structure |
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