| Synthesis and Crystal Structure of 2-Benzylamino-6-methyl-3-cyano-8- phenyl-5H-bispyrazolo[3,4-d,3'''',2''''-b]pyrimidine |
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| 引用本文： | YANG Li-Min LI Hong-Xia LIU Zhao-Jie① (Key Laboratory of Pesticide & Chemical Biology of Education Ministry,College of Chemistry,Central China Normal University,Wuhan 430079,China). Synthesis and Crystal Structure of 2-Benzylamino-6-methyl-3-cyano-8- phenyl-5H-bispyrazolo[3,4-d,3'''',2''''-b]pyrimidine[J]. 结构化学, 2005, 24(8) |
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| 作者姓名： | YANG Li-Min LI Hong-Xia LIU Zhao-Jie① (Key Laboratory of Pesticide & Chemical Biology of Education Ministry College of Chemistry Central China Normal University Wuhan 430079 China) |
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| 作者单位： | Key Laboratory of Pesticide & Chemical Biology of Education Ministry，College of Chemistry，Central China Normal University，Wuhan 430079，China |
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| 摘 要： | 1 INTRODUCTION The pyrazolopyrimidines have attracted conside- rable attention due to their versatile physiological activities, and a number of them exhibit excellent fungicidal[1], antiphlogistic[2～4] and antiumor[5] acti- vities. However, our interest in pyrazolo- pyrimidine stems is their applications as bactericide[6]. Herein we report the synthesis and structure of a tricyclic ring system bispyrazolo[3,4-d, 3?,2?-b]pyrimidine 1. 2 EXPERIMENTAL The 1H NMR spectra (CDCl3) were …
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Synthesis and Crystal Structure of 2- Be nzylamino-6- methyl- 3-cyano-8- phenyl-5H-bispyrazolo[3,4-d,3'''',2''''-b]pyrimidine |
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| YANG Li-Min,LI Hong-Xia,LIU Zhao-jie. Synthesis and Crystal Structure of 2- Be nzylamino-6- methyl- 3-cyano-8- phenyl-5H-bispyrazolo[3,4-d,3'''',2''''-b]pyrimidine[J]. Chinese Journal of Structural Chemistry, 2005, 24(8) |
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| Authors: | YANG Li-Min LI Hong-Xia LIU Zhao-jie |
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| Abstract: | The title compound 2-benzylamino-6-methyl-3-cyano-8-phenyl-5H-bispyrazolo[3,4-d,3',2'-b]pyrimidine crystallizes in orthorhombic, space group Pbca with a = 17.945(7), b =10.862(4), c = 19.481(7)(。A), β = 90°, Z = 8, V = 1151.8(4)(。A)3, Mr = 379.43, Dx = 1.327 g/cm3,μ(MoKα) = 0.084 mm 1, F(000) = 1584, the final R = 0.0513 and wR = 0.1128 for 2608 observed reflections (I ＞ 2σ(I)).X-ray analysis reveals that the tricyclic portion of the molecule is effectively planar.In addition, there exist three intermolecular hydrogen bonds. |
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| Keywords: | crystal structure bispyrazolo[3 4-d 3' 2'-b]pyrimidine synthesis |
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