| 苯乙胺衍生的手性膦-亚磷酰胺酯配体在Rh-催化a-烯醇酯膦酸酯的不对称氢化反应中的应用 |
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| 引用本文： | 胡向平. 苯乙胺衍生的手性膦-亚磷酰胺酯配体在Rh-催化a-烯醇酯膦酸酯的不对称氢化反应中的应用[J]. 分子催化, 2012, 26(6): 487-492 |
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| 作者姓名： | 胡向平 |
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| 作者单位： | 中国科学院大连化学物理研究所 |
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| 基金项目： | The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan) |
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| 摘 要： | 将苯乙胺衍生的手性膦-亚磷酰胺酯配体应用在Rh-催化α-烯醇酯膦酸酯的不对称氢化反应中,考察了配体结构及反应条件对反应结果的影响,并在优化的条件下研究了各种底物的适用范围,产物的对映选择性最高>99%ee.
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| 关 键 词： | 不对称催化 铑 膦-亚磷酰胺酯配体 α-烯醇酯膦酸酯 氢化 |
| 收稿时间： | 2012-11-08 |
| 修稿时间： | 2012-12-01 |
Rh-Catalyzed Asymmetric Hydrogenation of a-Enol Ester Phosphonates with 1-Phenylethylamine-Derived Phosphine-Phosphoramidite Ligands |
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| HU Juan,WANG Dao-yong,ZHENG Zhuo,HU Xiang-ping. Rh-Catalyzed Asymmetric Hydrogenation of a-Enol Ester Phosphonates with 1-Phenylethylamine-Derived Phosphine-Phosphoramidite Ligands[J]. Journal of Molecular Catalysis (China), 2012, 26(6): 487-492 |
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| Authors: | HU Juan WANG Dao-yong ZHENG Zhuo HU Xiang-ping |
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| Affiliation: | *(Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China) |
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| Abstract: | A series of phosphine-phosphoramidite ligands derived from commercially available, inexpensive chiral 1-phenylethylamine were employed in the Rh-catalyzed asymmetric hydrogenation of various a-enol ester phosphonates. The results indicated that the ligand (Sc,Sa)-2b bearing a Me-group on amino moiety exhibited similar enantioselectivity but superior catalytic activity to (Rc,Ra)-THNAPhos. Excellent enantioselectivities (up to >99% ee) and high catalytic activity (S/C up to 5000) have been achieved in the hydrogenation of various b-alkyl and b-aryl substituted substrates, demonstrating the high potential of this phosphine-phosphoramidite ligand in the preparation of optically active a-hydroxyphosphonates |
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| Keywords: | asymmetric catalysis rhodium phosphine-phosphoramidite ligand a-enol ester phosphonate hydrogenation |
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