The total synthesis of the annonaceous acetogenin, muricatetrocin C |
| |
Authors: | Dixon Darren J Ley Steven V Reynolds Dominic J |
| |
Institution: | Department of Chemistry, University of Cambridge Lensfield Road, Cambridge, CB2 1EW, UK. |
| |
Abstract: | The total synthesis of the potential antitumour agent muricatetrocin C has provided an ideal stage for the exploitation and development of new chemistry. A convergent synthetic strategy has been realised incorporating three distinct pieces of methodology, these include a highly diastereoselective hetero-Diels-Alder reaction to construct the butenolide terminus, an oxygen to carbon rearrangement to install the trans-2,5-disubstituted tetrahydrofuran ring and a spatial desymmetrisation process to afford the anti-diol unit. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|