Direct carboxylation of aromatic compounds using the sodium hydrogen carbonate/triphenylphosphine ditriflate system |
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| Authors: | Mohammad M Khodaei Abdolhamid Alizadeh Hadis A Hezarkhani |
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| Institution: | Department of Organic Chemistry, Razi University, Kermanshah 67149-67346, Iran |
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| Abstract: | A new procedure was developed for the highly regioselective synthesis of aromatic carboxylic acids using the sodium hydrogen carbonate/triphenylphosphine ditriflate system in ethanol at room temperature. This metal-free system was used for the carboxylation of thiophenol with unexpected products in terms of selectivity. The simplicity of the procedure, readily available aromatic compounds, short reaction times, and mild reaction conditions are other advantages of this protocol. |
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| Keywords: | Triphenylphosphine ditriflate Carboxylic acids Arenes Sodium hydrogen carbonate Electrophilic substitution |
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