Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation |
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Authors: | Gang Chen Jiao Lin Jie Zhang Ya Wu Xuefan Gu Xiaojiang Hao Yu Zhang |
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Institution: | 1. College of Chemistry and Chemical Engineering, Xi''an Shiyou University, Xi''an, Shaanxi 701165, PR China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China |
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Abstract: | In this study, a series of 3-ethyl-3-hydroxy-indole-2-ones were synthesized through the addition reaction of Et2Zn and N-substituted isatin by an autocatalytic process. The synthesized compounds were characterized by NMR spectroscopy and mass spectrometry, and the reaction mechanism was discussed. The antitumor and neuroprotection activities of these compounds were evaluated. The results showed that several compounds display protection activity on H2O2-induced apoptosis of PC12 cells, which are more effective than that of (±)-α-tocopherol Vitamin E (VE). Moreover, these compounds also show antitumor activity against A549 and P388 cell lines. |
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Keywords: | Isatin 3-Ethyl-3-hydroxy-indole-2-one Antitumor Neuroprotection |
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