Ring-closing metathesis of fluoroalkenes toward the synthesis of fluorinated heterocycles containing an oxaza bond |
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Authors: | David Guérin Isabelle Dez Annie-Claude Gaumont Xavier Pannecoucke Samuel Couve-Bonnaire |
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Institution: | 1. Normandie Université, ENSICAEN, Unicaen, CNRS, LCMT, 14000 Caen, France;2. Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA, 76000 Rouen, France |
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Abstract: | This study reports the ring-closing metathesis reaction of bisolefins, including a reluctant fluoroalkenes, linked with oxaza moiety. The resulting heterocycles were produced in high yields under high diluting conditions disfavoring the homodimerization side reaction of nonfluorinated double bond. The use of a mixture of solvents proved to be a good strategy to obtain the fluorinated heterocycles in fair to excellent yields. |
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Keywords: | Fluoroalkenes Olefin metathesis Ruthenium Heterocycles |
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