Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase--a key enzyme in M. tuberculosis cell wall biosynthesis |
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| Authors: | Cren Sylvaine Gurcha Sudagar S Blake Alexander J Besra Gurdyal S Thomas Neil R |
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| Affiliation: | School of Chemistry, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, UKNG7 2RD. |
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| Abstract: | Two iminosugars have been designed and synthesized as potential inhibitors of UDP-Galf transferase, an enzyme involved in Mycobacterium tuberculosis cell wall biosynthesis. The design is based on a proposed model of the transition state for the transferase reaction. One of the two racemic compounds is the first reported inhibitor of the target enzyme from M. smegmatis. |
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