[1,2,4]三唑并[3,4-b][1,3,4]噻二嗪类衍生物的合成及生物活性研究进展

[1,2,4]三唑并[3,4-b][1,3,4]噻二嗪作为极具前景的活性基团,在抗菌、抗肿瘤等方面具有多种药理活性,在药物和化学领域受到了广泛的关注。本文以含三唑并噻二嗪结构化合物的合成及其在抗肿瘤、抗菌等方面的生物活性为依据,对近几年国内外关于[1,2,4]三唑并[3,4-b][1,3,4]噻二嗪类化合物的研究进行分析总结,以期为后续该类新型抗肿瘤化合物的设计合成提供参考。

Progress in Syntheses and Biological Activities of[1,2,4]Triazolo[3,4-b] [1,3,4]thiadiazine Derivatives

The [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine as a promising active group has received extensive attention because of its pharmacological activities in antibacterial, anti-tumor and other aspects in the field of medicine and chemistry. In this paper, based on the synthesis of compounds containing triazolidazide structure and their anti-tumor, antibacterial and other activities in recent years, the research on [1,2,4] triazolazine [3,4-b] [1,3,4] thiadiazine compounds was analyzed and summarized, so as to provide reference for the design and synthesis of these novel antitumor compounds.