聚乙二醇化壳聚糖的制备及其应用研究进展

聚乙二醇(PEG)是一种具有无毒、亲油亲水、高生物相容和无免疫原性等特点的化合物。将聚乙二醇结构引入壳聚糖(CTS)糖链中得到的聚乙二醇化壳聚糖,不但保持了CTS的天然性和优良生物降解等特性,还具有更好的水溶性和对有机化合物的结合能力。通过对CTS进行聚乙二醇化改性,可进一拓展其应用领域。本文结合近20年国内外PEG改性CTS的研究特点,围绕PEG改性CTS的制备及其在药物负载与控制释放、组织工程、抗菌材料、生物活性物传递和环境保护等领域的应用进行了总结,并展望其未来的发展趋势。

Progress in Preparation and Application of PEGylated Chitosans

Polyethylene glycol (PEG) is one of non-toxic compound which characterized with lipophilic and hydrophilic, high biocompatibility and non-immunogenicity. Chitosan (CTS) can be transformed into PEGylated chitosan by introducing PEG into its sugar chain. PEGylated chitosans can not only maintain the natural and excellent biodegradability, but also enhance the water solubility and binding ability of chitosan to organic compounds. The fields concerned with the application of CTS can be expanded through PEGylated modification. On basis of the relevant research traits in the past 20 years, the preparation of PEGylated chitosans and their its application in the domains of drug loading and controlled release, tissue engineering, antibacterial materials, bioactive material delivery and environmental protection were summarized, and the future development trend is prospected.