Highly efficient alkene epoxidation and aziridination catalyzed by iron(II) salt + 4,4',4'-trichloro-2,2':6',2'-terpyridine/4,4'-dichloro-4'-O-PEG-OCH3-2,2':6',2'-terpyridine |
| |
| Authors: | Liu Peng Wong Ella Lai-Ming Yuen Angella Wing-Hoi Che Chi-Ming |
| |
| Institution: | Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China. |
| |
| Abstract: | "Iron(II) salt + 4,4',4'-trichloro-2,2':6',2'-terpyridine" is an effective catalyst for epoxidation and aziridination of alkenes and intramolecular amidation of sulfamate esters. The epoxidation of allylic-substituted cycloalkenes achieved excellent diastereoselectivities up to 90%. ESI-MS results supported the formation of iron-oxo and -imido intermediates. Derivitization of Cl 3terpy to O-PEG-OCH 3-Cl 2terpy renders the terpyridine unit to be recyclable, and the "iron(II) salt + 4,4'-dichloro-4'- O-PEG-OCH 3-2,2':6',2'-terpyridine" protocol can be reused without a significant loss of catalytic activity in the alkene epoxidation. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
