HPLC analysis of metabolically produced formaldehyde |
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| Authors: | Lengyel J Kalász H Szarvas T Peltz Cs Szarkáné-Bolehovszky A |
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| Affiliation: | Semmelweis University, 1089 Budapest, Nagyvárad ter 4, Hungary. |
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| Abstract: | Radiolabelled (-)-deprenyl is orally administered to rats, and urinary elimination of radiolabelled formaldehyde is detected. The separation is performed using high-performance liquid chromatography on octadecyl-silica stationary phase. Both the radioactivity and the UV absorbance of the dinitrophenylhydrazine formaldehyde peak are determined. Formaldehyde generation takes place by N-demethylation. Low levels of formaldehyde may have a beneficial role in counterbalancing the oxidative stress of the everyday person's life. |
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