Target-driven selection in a dynamic nitrone library |
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| Authors: | Turega Simon M Lorenz Christiane Sadownik Jan W Philp Douglas |
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| Institution: | EaStCHEM and Centre for Biomolecular Sciences, School of Chemistry, University of St Andrews, St Andrews, Fife, UKKY16 9ST. d.philp@st-andrews.ac.uk. |
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| Abstract: | Nitrones undergo dynamic exchange in chloroform at room temperature through two mechanisms-hydrolysis and recombination or hydroxylamine addition/elimination; this dynamic exchange is harnessed to select a nitrone-based bis(amidopyridine) receptor for diacids from a group of four nitrones through its binding to a glutaric acid-based target. |
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