Highly efficient synthesis of amides via Ritter chemistry with ionic liquids |
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| Authors: | Rajesh G. KalkhambkarSarah N. Waters Kenneth K. Laali |
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| Affiliation: | Department of Chemistry, University of North Florida, 1, UNF Drive, Jacksonville, FL 32224, USA |
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| Abstract: | The utility of Brønsted-acidic imidazolium ionic liquid [BMIM(SO3H)][OTf] as catalyst for the high yield synthesis of a wide variety of amides under mild conditions via the Ritter reaction of alcohols with nitriles has been demonstrated. As alternative methods for the carbocation generation step, NOPF6 immobilized in [BMIM][PF6] ionic liquid was used in the Ritter reaction of bromides with nitriles and for the synthesis of adamantyl amides from adamantane and nitriles. |
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| Keywords: | Ritter reaction Amides Ionic liquids Carbocations |
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