| 糖尿病肾病患者AR基因表达量测定 |
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| 引用本文： | 何永鑫,李雪,范雪梅,王琬,王义明,罗国安.糖尿病肾病患者AR基因表达量测定[J].高等学校化学学报,2010,31(2):293-295. |
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| 作者姓名： | 何永鑫 李雪 范雪梅 王琬 王义明 罗国安 |
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| 作者单位： | 1. 清华大学化学系,
2. 医学院, 北京 100084;
3. 华东理工大学药学院, 上海 200237 |
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| 基金项目： | 国家“九七三”计划项目(批准号:2005CB523503)资助 |
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| 摘 要： | 对50例正常人和80名糖尿病肾病不同分期的患者进行醛糖还原酶(Aldose Reductase, AR)基因的表达量测定, 提示AR基因有望成为糖尿病肾病(DN)早期诊断的生物标志物以及DN治疗上潜在的药物靶点, 并且利用AR基因对DN的中医诊断进行了分子生物学验证.
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| 关 键 词： | 糖尿病肾病 醛糖还原酶 Taqman实时荧光定量 PCR |
| 收稿时间： | 2009-01-23 |
Determination of AR Gene Expression in Diabetic Nephropathy |
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| HE Yong-Xin,LI Xue,FAN Xue-Mei,WANG Wan,WANG Yi-Ming,LUO Guo-An.Determination of AR Gene Expression in Diabetic Nephropathy[J].Chemical Research In Chinese Universities,2010,31(2):293-295. |
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| Authors: | HE Yong-Xin LI Xue FAN Xue-Mei WANG Wan WANG Yi-Ming LUO Guo-An |
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| Institution: | 1. Department of Chemistry, ;
2. Department of Medical Science, Tsinghua University, Beijing 100084, China;
3. School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | Diabetic nephropathy(DN) is a common chronic diabetic microvascular complication.DN is closely related to polyol pathway of glycometabolism,and aldose reductase(AR) is a rate-limiting enzyme in polyol pathway.In order to study the AR expression level in patients with different stages of DN,AR gene expression was detected in 50 cases of normal subjects and 80 diabetic nephropathy patients with different stages.The results show that AR gene is expected to be a biomarker for early diagnosis of DN,as well as th... |
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| Keywords: | Diabetic nephropathy Aldose reductase Taqman real-time PCR |
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