| 去卵巢大鼠骨元素代谢紊乱机制研究 |
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| 引用本文： | 陈小燕,刘浩宇,张兆强,刘锡仪.去卵巢大鼠骨元素代谢紊乱机制研究[J].广东微量元素科学,2004,11(3):21-24. |
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| 作者姓名： | 陈小燕 刘浩宇 张兆强 刘锡仪 |
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| 作者单位： | 湛江中医学校,广东,湛江,524094;广东医学院,广东,湛江,524023 |
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| 摘 要： | 测定了去卵巢大鼠骨元素含量和血清相关激素和细胞因子含量，分析了去卵巢大鼠骨元素代谢紊乱的机制。将健康4月龄SD大鼠18只随机分成3组：正常对照组，假去卵巢大鼠组和去卵巢大鼠组。结果表明，去卵巢大鼠骨Ca、Mg、S、Mn、Zn等含量显著降低，P含量显著升高，血清E2、P、CT、GH等含量显著降低，IL-6、FSH、LH等含量显著升高。提示去卵巢大鼠骨元素代谢紊乱是雌激素水平下降与其他因素共同作用的结果。
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| 关 键 词： | SD大鼠 骨矿物元素 激素 细胞因子 |
| 文章编号： | 1006-446X(2004)03-0021-04 |
| 修稿时间： | 2004年2月1日 |
Mechanism of Confusion of Bone Mineral Element Metabolism in Ovariectomized Rats |
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| CHEN Xiao-yan ,LIU Hao-yu ,ZHANG Zhao-qiang ,LIU Xi-yi.Mechanism of Confusion of Bone Mineral Element Metabolism in Ovariectomized Rats[J].Trace Elements Science,2004,11(3):21-24. |
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| Authors: | CHEN Xiao-yan LIU Hao-yu ZHANG Zhao-qiang LIU Xi-yi |
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| Institution: | CHEN Xiao-yan 1,LIU Hao-yu 2,ZHANG Zhao-qiang 2,LIU Xi-yi 2 |
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| Abstract: | To investigate the mechanism of the confusion of bone mineral element metabolism in ovariectomized rats,18 female Sprague-Dawley(SD)rats were divided into 3 groups:(1)normal control;(2)sham ovariectomy;(3)ovariectomy(ovx).The results show that(1)Ca,Mg,S,Mn,Zn reduce obviously and P increase in the bone of the ovx rats;(2)E 2,P,CT,GH reduce obviously and IL 6,FSH,LH increase obviously.It suggests that mechanism of the confusion of bone mineral element metabolism in ovariectomized rats is due to the effect of E 2 reduction and other factors. |
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| Keywords: | SD rat bone mineral elements hormone cell factor |
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