Ionic liquid-aqueous solution ultrasonic-assisted extraction of three kinds of alkaloids from Phellodendron amurense Rupr and optimize conditions use response surface |
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| Affiliation: | 1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China;2. Key Laboratory of Forest Plant Ecology (Northeast Forestry University), Ministry of Education, 332# No. 26 Hexing Road, Harbin City, Heilongjiang Province 150040, China;1. Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, 150040 Harbin, China;2. School of Forestry, Northeast Forestry University, 150040 Harbin, China;1. School of Public Health, Guangdong Medical University, Dongguan, China;2. Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China;1. School of Chemistry, University of Melbourne, Parkville, Vic 3010, Australia;2. Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia;3. Adjunct Professor, Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia;1. Institute for Sustainable Process Technology, Groen van Prinstererlaan 37, 3818 JN Amersfoort, The Netherlands;2. University of Twente, Sustainable Process Technology Group, Faculty of Science and Technology, PO Box 217, 7500 AE Enschede, The Netherlands;3. Syncom BV, Kadijk 3, 9747 AT Groningen, The Netherlands;4. DSM Fibre Intermediates B.V., Urmonderbaan 22, 6167 RD Geleen, The Netherlands |
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| Abstract: | In this paper, we chose diffident kinds of ionic liquids to optimal selection an optimal one to extract alkaloids from Phellodendron amurense Rupr. Four ionic liquids with diffident carbon chains or anions have been investigated and 1-butyl-3-methylimidazolium bromide with best productivity. Then, selections have been optimized in different conditions, including concentration of ionic liquid, time for ultrasonic treatment, ultrasonic power and solid–liquid ratio. Moreover, three conditions have been comprehensively assessment by response surface methodology, the optimal conditions were determined as follows ultrasonic power 100 W, extraction time 75 min and ratio of solvent to raw material 1:14. Under these conditions, the yield% (MIX) was 106.7% (extracted by heat reflux being defined 100%). Comparing with other methods, the advantages are saving conserving, time saving, high yield% and especially pollution-free. |
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| Keywords: | Ionic liquid Ultrasonic Extraction Response surface |
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