Fabrication of polymeric nanocapsules from curcumin-loaded nanoemulsion templates by self-assembly |
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| Affiliation: | 1. State Key Laboratory of Food Science & Technology, School of Food Science & Technology, Jiangnan University, Wuxi 214122, Jiangsu, China;2. Department of Chemistry, COMSATS Institute of Information Technology, Abbotabad 22060, Pakistan;1. Chemistry Institute of the Tajikistan Academy of Sciences, Dushanbe 734063, Tajikistan;2. Department of Food Materials and Process Design Engineering, Faculty of Food Science and Technology, University of Agricultural Sciences and Natural Resources, Gorgan, Iran;3. Kaunas University of Technology, Kaunas 44029, Lithuania;4. Beuth University of Applied Sciences, Department of Pharmaceutical Technology, Berlin 13353, Germany;1. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, People’s Republic of China;2. Center for Water Soluble Polymers, Glyndwr University, Wrexham, Wales, LL11 2AW, UK;3. National Institute of Food Science and Technology, Faculty of Food, Nutrition & Home Sciences, University of Agriculture, Faisalabad, 38040, Pakistan;4. Department of Food Science and Nutrition, Government College University Faisalabad, Sahiwal Campus, 57000, Pakistan;1. Stranski-Laboratorium fuer Physikalische and Theoretische Chemie, Institut fuer Chemie, Strasse des 17.Juni 124, Sekr. TC7, Technische Universitaet Berlin, D-10623 Berlin, Germany;2. Institut fuer Textilchemie und Chemiefasern (ITCF), Koerschtalstrasse 26, 73770 Denkendorf, Germany;1. College of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China;2. Biopolymers and Colloids Laboratory, Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA;3. Research and Development Department, Zhejiang Medicine Co., Ltd, Xinchang Pharmaceutical Factory, 59 East Huancheng Road, Shaoxing, Zhejiang 312500, China |
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| Abstract: | In this study, biodegradable polymeric nanocapsules were prepared by sequential deposition of food-grade polyelectrolytes through the self-assembling process onto the oil (medium chain triglycerides) droplets enriched with curcumin (lipophilic bioactive compound). Optimum conditions were used to prepare ultrasound-assisted nanoemulsions stabilized by octenyl-succinic-anhydride (OSA)-modified starch. Negatively charged droplets (−39.4 ± 1.84 mV) of these nanoemulsions, having a diameter of 142.7 ± 0.85 nm were used as templates for the fabrication of nanocapsules. Concentrations of layer-forming cationic (chitosan) and anionic (carboxymethylcellulose) biopolymers were optimized based on the mean droplet/particle diameter (MDD/MPD), polydispersity index (PDI) and net charge on the droplets/capsules. Prepared core–shell structures or nanocapsules, having MPD of 159.85 ± 0.92 nm, were characterized by laser diffraction (DLS), ζ-potential (ZP), atomic force microscopy (AFM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). Furthermore, physical stability of curcumin-loaded nanocapsules in suspension was determined and compared at different storage temperatures. This study may provide information regarding the formation of ultrasound-assisted polymeric nanocapsules from the nanoemulsion templates which could be helpful in the development of delivery systems for lipophilic food bioactives. |
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| Keywords: | Sonication Polyelectrolytes Nanoemulsion template Nanocapsules Microscopy |
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