Synthesis of [14C] quincetone |
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| Authors: | Jianyong Li Yunshang Yang Junxi Liu Rongcai Zhao Fenyi Yu Runhua Lu |
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| Affiliation: | (1) Laboratory of Nanoscale Biomedicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P.O. Box 201800, Shanghai, P.R. China;(2) Laboratory of Nanoscale Biomedicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P.O. Box 201800, Shanghai, P.R. China;(3) Laboratory of Nanoscale Biomedicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P.O. Box 201800, Shanghai, P.R. China;(4) Laboratory of Nanoscale Biomedicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P.O. Box 201800, Shanghai, P.R. China;(5) Shanghai Jiaotong University of Chinese, P.O. Box 200030, Shanghai, P.R. China;(6) Laboratory of Nanoscale Biomedicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P.O. Box 201800, Shanghai, P.R. China |
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| Abstract: | Summary The water-soluble fullerene derivative C60(OH)x was radiolabeled with 67GaCl3. The labeling yields were determined by radio-PLC. The effects of pH, reaction time, temperature and the amount of C60(OH)x on the labeling yields were studied. The stability of 67Ga-C60(OH)x was also examined. The results showed that the labeling yields could reach 97% under the best labeling conditions and the radiochemical purity of 67Ga-C60(OH)x solution kept at 37 °C remained at 88% after 212 hours. The biodistribution studies of 67Ga-C60(OH)x in mice showed a high localization of 67Ga-C60(OH)x in the bone marrow, bone, liver and spleen with slow clearance and a negligible accumulation in the blood. These data suggest that the water-soluble C60(OH)x, having the same properties as microcolloids, may be used as a carrier of drug system for lymphatic targeting. |
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