CH Functionalization/Asymmetric Michael Addition Cascade Enabled by Relay Catalysis: Metal Carbenoid Used for CC Bond Formation |
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| Authors: | Dr. Dian‐Feng Chen Feng Zhao Yue Hu Prof. Dr. Liu‐Zhu Gong |
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| Affiliation: | 1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/～gonglz/index.html;2. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin (China) |
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| Abstract: | A combination of either ruthenium(II) or rhodium(II) complexes and quinine‐derived squaramide enables 3‐diazooxindoles, indoles, and nitroalkenes to undergo highly efficient asymmetric three‐component reactions, thus affording optically active 3,3′‐bis(indole)s through a consecutive C? C bond‐forming sequence, which turned out to be applicable to the facile total synthesis of (?)‐folicanthine. |
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| Keywords: | C H activation carbenoids multicomponent reactions natural products ruthenium |
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